TY - DATA T1 - Additional file 1: of Subchronic exposure to titanium dioxide nanoparticles modifies cardiac structure and performance in spontaneously hypertensive rats PY - 2019/06/24 AU - Stefano Rossi AU - Monia Savi AU - Marta Mazzola AU - Silvana Pinelli AU - Rossella Alinovi AU - Laura Gennaccaro AU - Alessandra Pagliaro AU - Viviana Meraviglia AU - Maricla Galetti AU - Omar Lozano-Garcia AU - Alessandra Rossini AU - Caterina Frati AU - Angela Falco AU - Federico Quaini AU - Leonardo Bocchi AU - Donatella Stilli AU - StĂŠphane Lucas AU - Matteo Goldoni AU - Emilio Macchi AU - Antonio Mutti AU - Michele Miragoli UR - https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_of_Subchronic_exposure_to_titanium_dioxide_nanoparticles_modifies_cardiac_structure_and_performance_in_spontaneously_hypertensive_rats/8318558 DO - 10.6084/m9.figshare.8318558.v1 L4 - https://ndownloader.figshare.com/files/15587657 KW - Titanium dioxide nanoparticles KW - Nanotoxicology KW - Cardiac electrophysiology KW - Cardiac fibrosis KW - Arrhythmias N2 - Figure S1. Spontaneous arrhythmic events. Different examples of arrhythmic events. Both, supraventricular (Supraventricular Extrasystole and Sinus Arrhythmia, SVA; Sinus Pause, SP) and ventricular (Atrio-ventricular block, AV block; Ventricular Extrasystole, VE) events were recorded. (PDF 324 kb) ER - TY - DATA T1 - Additional file 2: of Subchronic exposure to titanium dioxide nanoparticles modifies cardiac structure and performance in spontaneously hypertensive rats PY - 2019/06/24 AU - Stefano Rossi AU - Monia Savi AU - Marta Mazzola AU - Silvana Pinelli AU - Rossella Alinovi AU - Laura Gennaccaro AU - Alessandra Pagliaro AU - Viviana Meraviglia AU - Maricla Galetti AU - Omar Lozano-Garcia AU - Alessandra Rossini AU - Caterina Frati AU - Angela Falco AU - Federico Quaini AU - Leonardo Bocchi AU - Donatella Stilli AU - StĂŠphane Lucas AU - Matteo Goldoni AU - Emilio Macchi AU - Antonio Mutti AU - Michele Miragoli UR - https://springernature.figshare.com/articles/journal_contribution/Additional_file_2_of_Subchronic_exposure_to_titanium_dioxide_nanoparticles_modifies_cardiac_structure_and_performance_in_spontaneously_hypertensive_rats/8318564 DO - 10.6084/m9.figshare.8318564.v1 L4 - https://ndownloader.figshare.com/files/15587669 KW - Titanium dioxide nanoparticles KW - Nanotoxicology KW - Cardiac electrophysiology KW - Cardiac fibrosis KW - Arrhythmias N2 - Figure S2. TEM analysis of the alveolar lung parenchyma from a SHR rat seven weeks after intratracheal instillation of TiO2-NPs. Individual or microaggregates of small electrondense NPs are present in the air space (As) as scattered within the alveolar septum in which a type II pneumocyte (PII) is recognized. NPs are also apparent in endothelial cells lining a capillary (*) and the lumen of a larger venule containing red blood cells (RBC) polymorphonuclear (PMN) neutrophils, lymphocytes (Lym) and platelets (arrow). Magnification 1800X. Scale Bar: 10Îźm. (PDF 2011 kb) ER - TY - DATA T1 - Additional file 3: of Subchronic exposure to titanium dioxide nanoparticles modifies cardiac structure and performance in spontaneously hypertensive rats PY - 2019/06/24 AU - Stefano Rossi AU - Monia Savi AU - Marta Mazzola AU - Silvana Pinelli AU - Rossella Alinovi AU - Laura Gennaccaro AU - Alessandra Pagliaro AU - Viviana Meraviglia AU - Maricla Galetti AU - Omar Lozano-Garcia AU - Alessandra Rossini AU - Caterina Frati AU - Angela Falco AU - Federico Quaini AU - Leonardo Bocchi AU - Donatella Stilli AU - Stéphane Lucas AU - Matteo Goldoni AU - Emilio Macchi AU - Antonio Mutti AU - Michele Miragoli UR - https://springernature.figshare.com/articles/journal_contribution/Additional_file_3_of_Subchronic_exposure_to_titanium_dioxide_nanoparticles_modifies_cardiac_structure_and_performance_in_spontaneously_hypertensive_rats/8318573 DO - 10.6084/m9.figshare.8318573.v1 L4 - https://ndownloader.figshare.com/files/15587684 KW - Titanium dioxide nanoparticles KW - Nanotoxicology KW - Cardiac electrophysiology KW - Cardiac fibrosis KW - Arrhythmias N2 - Figure S3. TBARS measurement in lungs evaluated in CTRL (white bars) and TiO2-NPs treated (black bars) animals. Two-way ANOVA (post hoc analyses: Bonferroni test) was performed and statistical significance was set at p<0.05. ● vs CTRL; * vs corresponding 1° week; # vs corresponding 3° week. Data are represented as mean ± SEM. (PDF 60 kb) ER - TY - DATA T1 - Additional file 4: of Subchronic exposure to titanium dioxide nanoparticles modifies cardiac structure and performance in spontaneously hypertensive rats PY - 2019/06/24 AU - Stefano Rossi AU - Monia Savi AU - Marta Mazzola AU - Silvana Pinelli AU - Rossella Alinovi AU - Laura Gennaccaro AU - Alessandra Pagliaro AU - Viviana Meraviglia AU - Maricla Galetti AU - Omar Lozano-Garcia AU - Alessandra Rossini AU - Caterina Frati AU - Angela Falco AU - Federico Quaini AU - Leonardo Bocchi AU - Donatella Stilli AU - StĂŠphane Lucas AU - Matteo Goldoni AU - Emilio Macchi AU - Antonio Mutti AU - Michele Miragoli UR - https://springernature.figshare.com/articles/journal_contribution/Additional_file_4_of_Subchronic_exposure_to_titanium_dioxide_nanoparticles_modifies_cardiac_structure_and_performance_in_spontaneously_hypertensive_rats/8318582 DO - 10.6084/m9.figshare.8318582.v1 L4 - https://ndownloader.figshare.com/files/15587705 KW - Titanium dioxide nanoparticles KW - Nanotoxicology KW - Cardiac electrophysiology KW - Cardiac fibrosis KW - Arrhythmias N2 - Table S1. List of primer sequences 5′-3′ used for real-time PCR analysis. (PDF 118 kb) ER -