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Additional file 9: Figure S3. of Anti-inflammatory potential of PI3Kδ and JAK inhibitors in asthma patients

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posted on 2016-10-04, 05:00 authored by Thomas Southworth, Jonathan Plumb, Vandana Gupta, James Pearson, Isabel Ramis, Martin Lehner, Montserrat Miralpeix, Dave Singh
Effects of Dexamethasone, PIK-294 and tofacinib on IL-6 from TCR-stimulated BAL cells. BAL cells from asthma patients (n = 5) were treated with varying concentrations of dexamethasone with or without 100nM of tofacitinib for 1 h before being stimulated with antibodies against CD3 and CD28 to induce a TCR-specific response. IL-6 was measured by ELISA. Data is presented as mean +/− standard deviation. Drug effects were analysed by 1-way ANOVA: p = 0.22. (PPTX 89 kb)

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