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Additional file 3 of Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson’s disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity

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posted on 2020-07-11, 04:06 authored by Rodney C. P. Go, Michael J. Corley, G. Webster Ross, Helen Petrovitch, Kamal H. Masaki, Alika K. Maunakea, Qimei He, Maarit I. Tiirikainen
Additional file 3: Figure S1. IPA® gene and function interconnection network of 15 genes with blood DML (p < 0.0001) that are associated with PD and other similar disorders, as derived from the comparison of PD cases with Plantation Work 10+ vs 0 years. Figure S2. IPA® gene and function interconnection network of 27 genes with blood DML (p < 0.001) that are associated with neurological development and abnormal brain morphology, as derived from the comparison of PD cases with 4+ OGCs and vs 0–2 OGCs.

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Michael J. Fox Foundation for Parkinson's Research U.S. Army Medical Research Acquisition Activity National Institute of Neurological Disorders and Stroke National Institute on Aging Office of Research and Development National Institutes of Health

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    BMC Neuroscience

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    Parkinson’s diseaseOrganochlorinesPlantation workGenome-wide DNA methylationGliaNeuroinflammationMitochondrial dysfunctionNeurodegeneration

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