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Additional file 2 of Plasma interferon-alpha is associated with double-positivity for autoantibodies but is not a predictor of remission in early rheumatoid arthritis—a spin-off study of the NORD-STAR randomized clinical trial

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posted on 2021-07-14, 03:50 authored by Marit Stockfelt, Anna-Carin Lundell, Merete Lund Hetland, Mikkel Østergaard, Till Uhlig, Marte Schrumpf Heiberg, Espen A. Haavardsholm, Michael T. Nurmohamed, Jon Lampa, Dan Nordström, Kim Hørslev Petersen, Bjorn Gudbjornsson, Gerdur Gröndal, Jonathan Aldridge, Kerstin Andersson, Kaj Blennow, Henrik Zetterberg, Ronald van Vollenhoven, Anna Rudin
Additional file 2:. Figure S2. Baseline IFNα protein levels do not predict remission in any of the treatment arms. Baseline IFNα protein levels in plasma from patients with early RA stratified according to DAS28-ESR 24 weeks after treatment initiation; in remission (DAS28-ESR < 2.6), low disease activity (2.6 < DAS28-ESR ≤ 3.2) or moderate/high disease activity (DAS28-ESR > 3.2) with A) all treatments, B) methotrexate + prednisone, C) methotrexate + TNFi, D) methotrexate + CTLA-4Ig and E) methotrexate + IL-6Ri. MTX (methotrexate), TNFi (certolizumab-pegol), CTLA-4Ig (abatacept), IL-6Ri (tocilizumab). Kruskal-Wallis test followed by Dunn’s multiple comparison test.

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Vetenskapsrådet ALF-agreement Stiftelsen Konung Gustaf V:s 80-årsfond Göteborgs Läkaresällskap The Academy of Finland Finska Läkaresällskapet Institutional grant of Helsinki University Hospital Alzheimer's Drug Discovery Foundation Swedish Alzheimer Foundation Hjärnfonden the European Union Joint Program for Neurodegenerative Disorders National Institutes of Health European Research Council The ALF agreement Olav Thon Foundation Familjen Erling-Perssons Stiftelse Stiftelsen för Gamla Tjänarinnor European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 860197 (MIRIADE) UK Dementia Research Institute at UCL University of Gothenburg

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    Arthritis Research & Therapy

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    RFRAdisease activity indextrial Abstract Backgroundanti-citrullinated protein antibodies24  weeksPre-treatment IFN α positivityIFN α protein levelsdisease activityILdisease activity scoreConclusion IFN α protein positivityNORD-STAR randomizedACPAIFN α protein positivityResults IFN α protein positivityPlasma IFN α protein levelsTNFIFN α systemCDAI remission 24  weeksNCTtreatment initiation

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