Additional file 2 of Evaluation of highly sensitive diagnostic tools for the detection of P. falciparum in pregnant women attending antenatal care visits in Colombia

Additional file 2: Figure S2. Superiority and equivalence of the hsRDT for the detection of P. falciparum during pregnancy compared to other diagnostic tests. A) Superiority testing between hsRDT and Microscopy/cRDT. Confidence Intervals (CI) of the difference between sensitivities compared to a superiority margin of + 15%. *One-sided comparative test not significant: p-value> 0.05. Dot: difference; bar: confidence interval; blue: area above the superiority margin. B) Equivalence testing between hsRDT, LAMP and nPCR. CIs of the difference between sensitivities compared to an equivalence margin of ±3%. * Two one-sided test (TOST) for equivalence not significant: p-value> 0.05. Dot: difference; thick bar: 90% CI; thin bar: 95% CI; green: area within the equivalence interval. cRDT (conventional Rapid Diagnostic Test); hsRDT (highly sensitive Rapid Diagnostic Test); nPCR (nested Polymerase Chain reaction), LAMP (Loop-mediated isothermal amplification), qRT-PCR (Quantitative Reverse Transcription polymerase chain reaction).