Additional file 1: Fig. S1. The experiment flow chart of this study was depicted. Fvb.B6 F1 female (brown color) hybrids were generated by crossing FVB/N-Tg(MMTV-PyMT)634Mul male (white color) mice to C57BL/6J female (black color) mice (Fig. S1A), Mammary tumors were harvested when the diameter of the largest tumor per mouse reached approximately 2 millimeters and 10 millimeters, which correspond to the Adenoma/MIN and late carcinoma stages. Lung metastases were harvested at the age of 13 weeks for Fvb mice and 16 weeks for F1 hybrids (Fig. S1B).
Funding
National Natural Science Foundation of China Science and Technology Planning Project of Guangdong Province Natural Science Foundation of Guangdong Province Young Teacher Foundation of Sun Yat-sen University Natural Science Foundation of Guangxi Provincial Department of Education (CN) Postdoctoral Research Foundation of China Sun Yat-sen University