MOESM3 of Structure, phylogeny, and expression of the frizzled-related gene family in the lophotrochozoan annelid Platynereis dumerilii

Additional file 2: Figure S1. Phylogenetic Analysis of Netrin domain containing proteins identifies PdsFRP3/4 and PdsFRP1/2/5, and indicates independent origins for the two sFRP gene families. Netrin domains of sFRPs and other NTR domain containing proteins were aligned in MAFFT and analyzed with Mr. Bayes. Nematostella vectensis TIMP was used as an outgroup. Posterior probabilities greater than 70 % are shown. P. dumerilii proteins are highlighted in red. P. dumerilii sFRP3/4 clusters with other sFRP3/4 s with high posterior probability confirming its identification as an sFRP3/4 homolog despite its highly derived CRD. The sFRP1/2/5 and sFRP3/4 subfamilies are highlighted with green and blue boxes, respectively. Species abbreviations: Bf, Brachiostoma floridae; Cg, Crassostrea gigas; Ct, Capitella teleta; Dr, Danio rerio; Gg, Gallus gallus; Hs, Homo sapiens; Nv, Nematostella vectensis; Pd, Platynereis dumerilii; Sk, Saccoglossus kowalevskii; Sp, Strongylocentrotus purpuratus; Xl, Xenopus laevis.