journal contribution
posted on 2021-08-04, 00:33 authored by Jessie BaldwinJessie Baldwin, Hannah Sallis, Tabea Schoeler, Mark Taylor, Alex Kwong, Laura D. Howe, Andrea Danese, Eamon McCroryEamon McCrory, Fruhling Rijsdijk, Jorim Tielbeek, Wikus BarkhuizenWikus Barkhuizen, Henrik Larsson, Sebastian Lundström, Robert Karlsson, Paul Lichtenstein, Marcus Munafò, Jean-Baptiste PingaultJean-Baptiste Pingault ABSTRACT: It is well established that children who grow up experiencing adversities (such as maltreatment, domestic violence, and parental mental illness) have an elevated risk of mental health problems. However, the extent to which different adverse childhood experiences cause mental health problems is not known. In particular, previously observed associations may partly reflect pre-existing genetic liability to mental health problems among children exposed to adversities. In this Registered Report, we will use DNA collected in more than 16,000 children from the United Kingdom and Sweden to investigate: (1) whether children with higher genetic liability to mental health problems are more likely to be exposed to different adversities, and (2) the extent to which genetic liability contributes to the associations between adverse childhood experiences and mental health. The findings will shed light on the potential genetic contribution to the associations between adverse childhood experiences and mental health, and help inform intervention approaches.
ITEMS: Stage 1 Registered Report Protocol, Stage 1 Registered Report Supplementary Information
Funding
The UK Medical Research Council and Wellcome (Grant Ref: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC data collection. A comprehensive list of grant funding is available on the ALSPAC website. GWAS data was generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. The Swedish Research Council for Health, Working Life and Welfare (2012-1678), the Swedish Research Council (2016-01989) and the Swedish Foundation for International Cooperation in Research and Higher Education (STINT) provide support for CATSS data collection. J.R.B is funded by a Wellcome Trust Sir Henry Wellcome fellowship (grant 215917/Z/19/Z). L.D.H is supported by a Career Development Award fellowship from the UK Medical Research Council (MR/M020894/1). H.M.S, A.S.F.K, M..M and L.D.H work in a unit that receives funding from the University of Bristol and the UK Medical Research Council (MC_UU_00011/5, MC_UU_00011/7).). H.M.S and M.R.M are supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at the University Hospitals Bristol National Health Service Foundation Trust and the University of Bristol. M.R.M and H.M.S are members of the UK Centre for Tobacco and Alcohol Studies, a UKCRC Public Health Research: Centre of Excellence. A.D was funded by the Medical Research Council (MRC; grant no. P005918) and by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. The funders have/had no role in study design, data analysis, decision to publish or preparation of the manuscript.
History
Preregistration details
The study protocol was preregistered with Nature Human Behaviour.Date of in-principle acceptance
2021-01-04
