Additional file 8 of Influence of complement protein C1q or complement receptor C5aR1 on gut microbiota composition in wildtype and Alzheimer’s mouse models

Additional file 8: Supplemental Figures. Figure S1. C1q is not detectable in plasma or hippocampus 6 months after tamoxifen treatment in RosaCre+ mice. Figure S2. The presence of the RosaCre transgene does not affect the alpha or beta diversity in vehicle treated WT C1qaFL/FL and Arctic C1qaFL/FL mice. Figure S3. Tamoxifen treatment did not alter the microbial diversity in WT and Arctic C1qaFL/FL mice lacking RosaCre. Figure S4. Deletion of C1qa in Arctic but not WT mice alters beta-diversity. Figure S5. Arctic mice have an increased alpha diversity independent of C1q deletion. Figure S6. Tamoxifen treatment of WT and Arctic mice with and without RosaCre demonstrates changes due to Arctic genotype and C1q deletion. Figure S7. PMX205 does not alter the microbiome of WT or Arctic mice. Figure S8. Bacteroidales levels increase with age in Tg2576 mice but remain lower than those in WT mice.