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Additional file 5 of PDGFRβ is an essential therapeutic target for BRCA1-deficient mammary tumors

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posted on 2021-01-23, 00:46 authored by Feng Bai, Shiqin Liu, Xiong Liu, Daniel P. Hollern, Alexandria Scott, Chuying Wang, Lihan Zhang, Cheng Fan, Li Fu, Charles M. Perou, Wei-Guo Zhu, Xin-Hai Pei
Additional file 5. BRCA1 represses transcription of PDGFRβ and EMT-associated genes. SUM149 cells were transfected with pBabe-empty (Empty), pBabe-HA-BRCA1 (BRCA1-a), or pBabe-Myc-BRCA1 (BRCA1-b). Expression of genes indicated in the cells were determined by western blot (A) and qRT-PCR (B) 48 h after transfection.

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National Natural Science Foundation of China Guangdong Provincial Science and Technology Program High Energy Physics Group, University of Mississippi (US) Natural Science Foundation of Guangdong Province DOD Idea Expansion Award American Cancer Society

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    Breast Cancer Research

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    BRCA1PDGFRβEMTMammary tumorTargeted therapy

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