Additional file 5 of Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons

Additional file 5: Fig. S3. Comparison of predictions from the four DNAm clocks in adult brain samples (n = 1221). Shown are scatterplots comparing chronological age (x-axis; years) against predicted epigenetic age (y-axis; years) calculated using A Fetal Brain Clock (FBC); B Horvath’s Multi Tissue Clock (MTC); C Knight’s Gestational Age Clock (GAC); D Lee’s Control Placental Clock (CPC) in an independent adult brain dataset. Where necessary, predicted age was converted to years, where 0 indicates birth. The black line indicates the identity line of chronological and predicted epigenetic age and represents a perfect prediction. Two statistics were calculated to evaluate the precision of each DNAm clock: Pearson’s correlation coefficient (r) and the root mean squared error (RMSE).