Additional file 3: of 
                     Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations

Duru, Valentine; Khim, Nimol; Leang, Rithea; Kim, Saorin; Domergue, Anais; Kloeung, Nimol; Ke, Sopheakvatey; Chy, Sophy; Eam, Rotha; Khean, Chanra; Loch, Kaknika; Ken, Malen; Lek, Dysoley; Beghain, Johann; Ariey, FrĂŠdĂŠric; Guerin, Philippe; Huy, Rekol; Mercereau-Puijalon, Odile; Witkowski, Benoit; Menard, Didier

doi:10.6084/m9.figshare.c.3619538_D1.v1

12916_2015_539_MOESM3_ESM.pdf (40.63 kB)

Additional file 3: of Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: retrospective and prospective investigations

journal contribution

posted on 2015-12-22, 05:00 authored by Valentine Duru, Nimol Khim, Rithea Leang, Saorin Kim, Anais Domergue, Nimol Kloeung, Sopheakvatey Ke, Sophy Chy, Rotha Eam, Chanra Khean, Kaknika Loch, Malen Ken, Dysoley Lek, Johann Beghain, FrĂŠdĂŠric Ariey, Philippe Guerin, Rekol Huy, Odile Mercereau-Puijalon, Benoit Witkowski, Didier Menard

Examples of interpretable piperaquine concentration-inhibition curves (Panel A) and non-interpretable piperaquine concentration-inhibition curves due to a paradoxical increase of apparent growth at high drug concentrations (Panel B: curves do not fit the data; Panel C: core criteria of curves are not acceptable). (PDF 40 kb)

Funding

Institut Pasteur (FR)

History

Usage metrics

Keywords

Artemisinin combination therapies Artemisinin resistance Cambodia Ex vivo testing Falciparum In-vitro testing Malaria Piperaquine resistance Treatment failure

Licence

CC BY + CC0

Exports

RefWorks

BibTeX

Ref. manager

Endnote

DataCite

NLM

DC