Additional file 3 of NOTCH2 variant D1853H is mutated in two non-syndromic premature ovarian insufficiency patients from a Chinese pedigree

Additional file 3 Fig. S3. Gene expression levels by RNA-seq analysis. (A) NOTCH signaling is activated in WT and 5557C (mut) groups. NOTCH2 was expressed at approximately 60 folds in WT and 5557C (mut) groups compared with the empty vector transfected group (Ctrl). Expression of HES5 and HES1 was high in WT and 5557C groups. (B) Different genes’ expressions between WT and 5557C groups.