13073_2020_754_MOESM3_ESM.pdf (1.69 MB)
Additional file 3 of Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults
journal contribution
posted on 2020-07-09, 05:28 authored by Robert F. Hillary, Daniel Trejo-Banos, Athanasios Kousathanas, Daniel L. McCartney, Sarah E. Harris, Anna J. Stevenson, Marion Patxot, Sven Erik Ojavee, Qian Zhang, David C. Liewald, Craig W. Ritchie, Kathryn L. Evans, Elliot M. Tucker-Drob, Naomi R. Wray, Allan F. McRae, Peter M. Visscher, Ian J. Deary, Matthew R. Robinson, Riccardo E. MarioniAdditional file 3. Details of Supplementary Methods. Contains information for the following data: Conditional and joint analysis from ordinary least squares GWAS on protein levels; Sherlock: identifying genes whose expression associates with inflammatory biomarkers; GWAS and EWAS of CCL11 levels – incorporating smoking status as a covariate; Replication of previous pQTLs and protein associated-CpG sites; BayesR+ combined analysis – GWAS and EWAS modelled together; Evaluating causal associations between blood inflammatory proteins and Alzheimer’s risk.
