Additional file 3: of Lineage-specific duplication of amphioxus retinoic acid degrading enzymes (CYP26) resulted in sub-functionalization of patterning and homeostatic roles

Comparative dating tree for the CYP26 subfamily. Divergence dates of the CYP26 sequences were estimated using fossil-based calibration intervals. Cladogram node dates represent estimation of the mean node height and the highest posterior density intervals fixed at 95% are shown in parentheses. Geological era abbreviations: Cam, Cambrian; Car, Carboniferous; Cre, Cretaceous; Dev, Devonian; Jur, Jurassic; Ord, Ordovician; Per, Permian; Sil, Silurian; Tri, Triassic. Species name abbreviations: B.b., Branchiostoma belcheri (in blue); B.f., Branchiostoma floridae (in red); B.l., Branchiostoma lanceolatum (in green); C.g., Crassostrea gigas; C.i., Ciona intestinalis; C.m., Callorhinchus milii; C.t., Capitella teleta; D.r., Danio rerio; G.a., Gasterosteus aculeatus; G.g., Gallus gallus; H.s., Homo sapiens; L.a. Lingula anatina; L.c., Latimeria chalumnae; L.e., Leucoraja erinacea; L.g., Lottia gigantea; L.j., Lethenteron japonicum; L.o., Lepisosteus oculatus; M.d., Monodelphis domestica; M.m., Mus musculus; O.b., Octopus bimaculoides; O.l., Oryzias latipes; P.c., Priapulus caudatus; P.f., Ptychodera flava; P.m., Petromyzon marinus; S.k., Saccoglossus kowalevskii; S.p., Strongylocentrotus purpuratus; T.r., Takifugu rubripes; X.t., Xenopus tropicalis. (PDF 271 kb)