Additional file 3 of Interleukin-6-knockdown of chimeric antigen receptor-modified T cells significantly reduces IL-6 release from monocytes

Kang, Liqing; Tang, Xiaowen; Zhang, Jian; Li, Minghao; Xu, Nan; Qi, Wei; Tan, Jingwen; Lou, Xiaoyan; Yu, Zhou; Sun, Juanjuan; Wang, Zhenkun; Dai, Haiping; Chen, Jia; Lin, Guoqing; Wu, Depei; Yu, Lei

doi:10.6084/m9.figshare.12444254.v1

40164_2020_166_MOESM3_ESM.pdf (2.9 MB)

Additional file 3 of Interleukin-6-knockdown of chimeric antigen receptor-modified T cells significantly reduces IL-6 release from monocytes

journal contribution

posted on 2020-06-08, 03:50 authored by Liqing Kang, Xiaowen Tang, Jian Zhang, Minghao Li, Nan Xu, Wei Qi, Jingwen Tan, Xiaoyan Lou, Zhou Yu, Juanjuan Sun, Zhenkun Wang, Haiping Dai, Jia Chen, Guoqing Lin, Depei Wu, Lei Yu

Additional file 3: Figure S3. Effect of IL-6 knockdown on ssCART-19 cell differentiation and gene expression. A Differentiation of ssCART-19 cells and regular CART-19 cells, as detected by flow cytometry, Tscm (stem central memory T cells), Tcm (central memory T cells), Tem (effector memory T cells), Teff (effector T cells). B Top differentially expressed genes in ssCART-19 and regular CART-19 cells after coculture with Raji cells, as analyzed by RNA sequencing. C Gene ontology enrichment analysis of the RNA sequencing data showing the top 30 enriched functions.