Additional file 3 of Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium

Kasela, Silva; Ortega, Victor E.; Martorella, Molly; Garudadri, Suresh; Nguyen, Jenna; Ampleford, Elizabeth; Pasanen, Anu; Nerella, Srilaxmi; Buschur, Kristina L.; Barjaktarevic, Igor Z.; Barr, R. Graham; Bleecker, Eugene R.; Bowler, Russell P.; Comellas, Alejandro P.; Cooper, Christopher B.; Couper, David J.; Criner, Gerard J.; Curtis, Jeffrey L.; Han, MeiLan K.; Hansel, Nadia N.; Hoffman, Eric A.; Kaner, Robert J.; Krishnan, Jerry A.; Martinez, Fernando J.; McDonald, Merry-Lynn N.; Meyers, Deborah A.; Paine, Robert; Peters, Stephen P.; Castro, Mario; Denlinger, Loren C.; Erzurum, Serpil C.; Fahy, John V.; Israel, Elliot; Jarjour, Nizar N.; Levy, Bruce D.; Li, Xingnan; Moore, Wendy C.; Wenzel, Sally E.; Zein, Joe; Langelier, Charles; Woodruff, Prescott G.; Lappalainen, Tuuli; Christenson, Stephanie A.

doi:10.6084/m9.figshare.14463075.v1

13073_2021_866_MOESM3_ESM.pdf (4.17 MB)

Additional file 3 of Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium

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posted on 2021-04-22, 03:40 authored by Silva Kasela, Victor E. Ortega, Molly Martorella, Suresh Garudadri, Jenna Nguyen, Elizabeth Ampleford, Anu Pasanen, Srilaxmi Nerella, Kristina L. Buschur, Igor Z. Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Russell P. Bowler, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Gerard J. Criner, Jeffrey L. Curtis, MeiLan K. Han, Nadia N. Hansel, Eric A. Hoffman, Robert J. Kaner, Jerry A. Krishnan, Fernando J. Martinez, Merry-Lynn N. McDonald, Deborah A. Meyers, Robert Paine, Stephen P. Peters, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John V. Fahy, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, Xingnan Li, Wendy C. Moore, Sally E. Wenzel, Joe Zein, Charles Langelier, Prescott G. Woodruff, Tuuli Lappalainen, Stephanie A. Christenson

Additional file 3: Figure S1. Associations between ACE2 gene expression and COPD, asthma, steroid use, and race. Figure S2. Associations between ACE2 gene expression and obesity. Figure S3. Associations between ACE2 gene expression and hypertension, and use of antihypertensives. Figure S4. Associations between age and ACE2 gene expression, and age and differential ACE2 exon usage. Figure S5. Associations between age and smoking status, hypertension, sex, and BMI in SPIROMICS. Figure S6. COVID-19 and other viral illness related gene set enrichment analyses in association with comorbidities in SPIROMICS, SARP, and MAST. Figure S7. Regulatory genetic effects of ACE2 and TMPRSS2, and the effect of smoking on TMPRSS2. Figure S8. Associations between COVID-19-related genes and comorbidities. Figure S9. Replication of cis-eQTLs in GTEx. Figure S10. Regulatory genetic effects of the candidate genes in the chr3 cluster associated with COVID-19. Figure S11. PheWAS associations for the 44 out of 108 lead cis-eQTLs associated with COVID-19-related genes with Phenoscanner v2.

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National Institute of Mental Health National Heart, Lung, and Blood Institute National Institute of General Medical Sciences National Human Genome Research Institute

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COVID-19 SARS-CoV-2 ACE2 eQTL Bronchial epithelium

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Additional file 3 of Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium

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National Institute of Mental Health National Heart, Lung, and Blood Institute National Institute of General Medical Sciences National Human Genome Research Institute

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