Additional file 2 of The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota

Additional file 1: Fig. S1. p-Cresol treatment does not impact general physiological parameters, increases urinary and fecal p-Cresol excretion but not its serum levels. Fig. S2. p-Cresol treatment-induced behavioral alterations: additional parameters in the 3-chamber, dyadic social interactions and stereotypies tests and results from tests assessing locomotor activity, anxiety or cognition (relative to Fig. 1). Fig. S3. Autistic-like behaviors persist after discontinuation of p-Cresol for 4 weeks. Fig. S4. Additional behavioral parameters for the 3-chamber, dyadic social interactions, motor stereotypies tests and anxiety in FMTControl and FMTp-Cresol mice (relative to Fig. 4). Fig. S5. p-Cresol microbial biosynthetic pathways (relative to Fig. 5). Fig. S6. FMT experiments from control donors (FMTControl) to Control or p-Cresol-treated recipient mice: additional behavioral parameters in the 3-chamber, dyadic social interactions and stereotypies tests (relative to Fig. 6). Tab. S5: Recapitulation of the behavioral tests performed in the course of the study.