Additional file 2 of Targeting PPARα in the rat valproic acid model of autism: focus on social motivational impairment and sex-related differences

Additional file 2: Behavioral effects of a 14-week FBR administration on social deficits and perseverative behavior in adult ASD-like rats. Figure S1. The time spent exploring the social stimulus (A), the sociability index (SI) (B), and the number of social interactions (C) were scored. (A) Two-way ANOVA, VPA exposure: F1, 36 = 11.97, p = 0.0014; FBR administration: F1, 36 = 10.36, p = 0.027; interaction: F1, 36 = 5.33, p = 0.0267; post hoc comparison: ** p < 0.01 vs. Saline-SD group; ##p < 0.01 vs. VPA-SD group. (B) Two-way ANOVA, VPA exposure: F1,36 = 9.48, p = 0.004; FBR administration: F1, 36 = 4.12, p = 0.0496; interaction: F1, 36 = 4.721, p = 0.0365; post hoc comparison: **p < 0.01 vs. Saline-SD group; #p < 0.05 vs. VPA-SD group. (C) Two-way ANOVA, VPA exposure: F1, 36 = 11.83, p = 0.0015; FBR administration: F1, 36 = 12.89, p = 0.0010; interaction: F1, 36 = 4.641, p = 0.0380; post hoc comparison: **p < 0.01 vs. Saline-SD group; ##p < 0.01 vs. VPA-SD group. (D) Two-way ANOVA, VPA exposure: F1, 36 = 8.46, p = 0.0062; FBR administration: F1, 36 = 1.085, n.s.; interaction: F1, 36 = 7.65, p = 0.0089; post hoc comparison: **p < 0.01 vs. Saline-SD group; #p < 0.05 vs. VPA-SD group. Values are expressed as means ± SEM; n = 10.