Additional file 2 of FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment—a pharmacokinetic-pharmacodynamic study

Paterson, L. M.; Barker, D.; Cro, S.; Mozgunov, P.; Phillips, R.; Smith, C.; Nahar, L.; Paterson, S.; Lingford-Hughes, A. R.

doi:10.6084/m9.figshare.21358110.v1

13063_2022_6821_MOESM2_ESM.docx (19.73 kB)

Additional file 2 of FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment—a pharmacokinetic-pharmacodynamic study

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posted on 2022-10-19, 03:23 authored by L. M. Paterson, D. Barker, S. Cro, P. Mozgunov, R. Phillips, C. Smith, L. Nahar, S. Paterson, A. R. Lingford-Hughes

Additional file 2. Exploratory objectives, hypotheses, outcomes and planned analyses.

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NIHR Imperial Biomedical Research Centre Central and North West London NHS Foundation Trust Medical Research Council

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Opiate Addiction Dependence GABA-B Baclofen Methadone Phase I Dose escalation Adaptive Bayesian

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Additional file 2 of FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment—a pharmacokinetic-pharmacodynamic study

Funding

NIHR Imperial Biomedical Research Centre Central and North West London NHS Foundation Trust Medical Research Council

History

Usage metrics

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Keywords

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