40246_2019_232_MOESM1_ESM.doc (5.97 MB)
Additional file 1: of Three miRNAs cooperate with host genes involved in human cardiovascular disease
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posted on 2019-08-30, 04:38 authored by Yan Zhu, Jingjing Xie, Hong SunFigure S1. Schematic representation of the study design. Figure S2. Genomic location and sequence conservation of the human miR-3182 gene. A, Evolutionary conservation across 30 mammals is measured by PhastCons and PhyloP score. B, Pairwise alignment between the human miR-3182 gene and its gorila ortholog. Figure S3. Genomic location and sequence conservation of the human miR-6863 gene. Evolutionary conservation across 30 mammals is measured by PhastCons and PhyloP score. Figure S4. Genomic location and sequence conservation of the human miR-5582 gene. Evolutionary conservation across 30 mammals is measured by PhastCons and PhyloP score. Table S1. Targets of miR-3182 used for GSEA analysis. The NetWAS scores, which describe the probability of interaction between the host gene CDH13 and the predicted targets of miR-3182, are replaced by their fractional ranks. Validated targets are highlighted with a star. Table S2. Targets of miR-6863 used for GSEA analysis. The NetWAS scores, which describe the probability of interaction between the host gene SLC12A3 and the predicted targets of miR-5582, are replaced by their fractional ranks. Validated targets are highlighted with a star. Table S3. Targets of miR-5582 used for GSEA analysis. The NetWAS scores, which describe the probability of interaction between the host gene CKAP5 and the predicted targets gene of miR-5582, are replaced by their fractional ranks. Validated targets are highlighted with a star. (DOC 6113 kb)
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PhyloP scorehost gene CDH 13miR -6863 geneTable S 3.30 mammalsTable S 2.Validated targetsTable S 1.Evolutionary conservationFigure S 4. Genomic locationsequence conservationFigure S 3. Genomic locationhost gene SLC 12Adisease Figure S 1. Schematic representationmiR -5582 geneFigure S 2. Genomic locationDOC 6113 kbhost gene CKAP 5GSEA analysismiR -3182 geneNetWAS scores
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