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Additional file 1 of Talniflumate abrogates mucin immune suppressive barrier improving efficacy of gemcitabine and nab-paclitaxel treatment in pancreatic cancer

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posted on 2023-11-24, 04:41 authored by Antonio Agostini, Ilaria Guerriero, Geny Piro, Giuseppe Quero, Luca Roberto, Annachiara Esposito, Alessia Caggiano, Lorenzo Priori, Giulia Scaglione, Francesco De Sanctis, Antonella Sistigu, Martina Musella, Alberto Larghi, Gianenrico Rizzatti, Donatella Lucchetti, Sergio Alfieri, Alessandro Sgambato, Emilio Bria, Laura Bizzozero, Sabrina Arena, Stefano Ugel, Vincenzo Corbo, Giampaolo Tortora, Carmine Carbone
Additional file 1: Figure S1. GCNT3, Vimentin, and N-cadherin expression throughout PDAC progression. a) Multiplex IF showing the expression of GCNT3, Vimentin, and N-cadherin in Low-grade IPMN, High-grade IPMN, locally advanced PDAC (pN0), metastatic PDAC (pN2) and matched metastasis. b) Barplots show percentage of positive cells per area in the 10 different ROI annotated by pathologist.

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Associazione Italiana per la Ricerca sul Cancro Agenzia Italiana del Farmaco, Ministero della Salute Ministero dell'Università e della Ricerca Ministero dell’Istruzione, dell’Università e della Ricerca

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    Journal of Translational Medicine

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    Keywords

    Intraductal mucinous neoplasms (IPMNs)Spatial transcriptomicsPancreatic ductal adenocarcinoma (PDAC)Organoid interaction platformSyngeneic mouse models

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