Additional file 1 of Serum urate and lung cancer: a cohort study and Mendelian randomization using UK Biobank

Additional file 1: Figure S1. Observational associations between serum urate and lung cancer incidence by smoking status and sex after adding one and two years between the urate test date and cohort entry. Figure S2. Observational associations between serum urate and FEV1 by sex adjusted for age, calendar year, ethnicity (first 40 principal components), height and recruitment centre (Model 1) and additionally for weight (Model 2). Non-linear relationships were captured using restricted cubic spline transformation with three knots placed at the 10th, 50th and 90th percentiles of urate levels. Figure S3. Observational associations between serum urate and FEV1 with interactions with smoking packyears in regular smokers by sex adjusted for age, calendar year, ethnicity (first 40 principal components), height, recruitment centre (Model 1) and additionally for weight (Model 2). Figure S4. Per allele effects on serum urate, baseline FEV1 and lung cancer incidence. Table S1. Association between genetically predicted urate using rs12498742 and rs2231142, FEV1 and lung cancer incidence. Table S2. The genetically instrumented cross-sectional relationships between urate and other outcomes