12916_2022_2702_MOESM1_ESM.docx (765.11 kB)
Additional file 1 of Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study
journal contribution
posted on 2023-04-13, 10:18 authored by Nikos Papadimitriou, Caroline J. Bull, Mazda Jenab, David J. Hughes, Joshua A. Bell, Eleanor Sanderson, Nicholas J. Timpson, George Davey Smith, Demetrius Albanes, Peter T. Campbell, Sébastien Küry, Loic Le Marchand, Cornelia M. Ulrich, Kala Visvanathan, Jane C. Figueiredo, Polly A. Newcomb, Rish K. Pai, Ulrike Peters, Kostas K. Tsilidis, Jolanda M. A. Boer, Emma E. Vincent, Daniela Mariosa, Marc J. Gunter, Tom G. Richardson, Neil MurphyAdditional file 1: Table S1. Beta estimates for genome-wide significant SNPs for early/adult life body size in UK Biobank (overall, men, women). Table S2. Summary information on colorectal cancer risk for the SNPs used in the analysis. Table S3. Number of cancer cases by sex and subsite. Table S4. Sample size and power calculations for each phenotype and group in the Mendelian randomization study of early and adult life body size and risk of colorectal cancer. Table S5. Beta estimates for early/adult life body size in UK Biobank for the SNPs included in the MVMR analysis (overall, men, women). Table S6. STROBE-MR checklist of recommended items to address in reports of Mendelian randomization studies. Table S7. Univariable Mendelian randomization estimates between early and adult body size and colorectal cancer risk. Table S8. Fearly life body size, Fadult body size and Qa in the multivariable MR between early, adult body size and colorectal cancer. Table S9. Multivariable MR Egger analysis to assess the effect of both predicted early life and adult body size on colorectal cancer.
