Additional file 1 of Safety, tolerability, pharmacokinetics and pharmacodynamics of single oral doses of BI 187004, an inhibitor of 11beta-hydroxysteroid dehydrogenase-1, in healthy male volunteers with overweight or obesity

Additional file 1: Supplementary Table 1. Summary of total urinary corticosteroids (aTHF + THF + UFF + UFE + THE) by time intervals. Supplementary Table 2. Summary of urinary THF (5alpha-THF + 5beta-THF)/THE ratio by time intervals and by placebo-corrected, baseline-adjusted gmeans. Supplementary Table 3. Baseline metabolic parameters. Supplementary Table 4. Individual drug plasma concentration of BI 187004 after single oral administration of 2.5 mg BI 187004 with descriptive statistics. Supplementary Table 5. Individual drug plasma concentration of BI 187004 after single oral administration of 5 mg BI 187004 with descriptive statistics. Supplementary Table 6. Individual drug plasma concentration of BI 187004 after single oral administration of 10 mg BI 187004 with descriptive statistics. Supplementary Table 7. Individual drug plasma concentration of BI 187004 after single oral administration of 20 mg BI 187004 with descriptive statistics. Supplementary Table 8. Individual drug plasma concentration of BI 187004 after single oral administration of 40 mg BI 187004 with descriptive statistics. Supplementary Table 9. Individual drug plasma concentration of BI 187004 after single oral administration of 80 mg BI 187004 with descriptive statistics. Supplementary Table 10. Individual drug plasma concentration of BI 187004 after single oral administration of 160 mg BI 187004 with descriptive statistics. Supplementary Table 11. Individual drug plasma concentration of BI 187004 after single oral administration of 240 mg BI 187004 with descriptive statistics. Supplementary Table 12. Individual drug plasma concentration of BI 187004 after single oral administration of 360 mg BI 187004 with descriptive statistics. Supplementary Table 13. Individual THF/THE ratio at baseline and after single ascending dose administrations in healthy volunteers. Supplementary Table 14. Individual cortisol levels in adipose tissue at baseline, 10 h and 24 h after single ascending dose administrations in healthy volunteers.