Additional file 1 of Right ventricular injury in critically ill patients with COVID-19: a descriptive study with standardized echocardiographic follow-up

Additional file 1: Figure S2: Alluvial plot with distribution of patients depending on their right ventricular (RV) injury pattern and status (alive or dead) from intensive care unit (ICU) admission to Day-28. 1. No RV injury (blue lines). 2. Isolated RV dilatation (green lines). 3. RV dysfunction without RV dilatation (yellow lines). 4. RV dysfunction with RV dilatation (red lines). 5. Acute cor pulmonale (black lines). 6. Alive. 7. Dead. Among the 65 patients without RV injury on ICU admission, 7(11%) experienced isolated RV dilation, 8(12%) experienced RV dysfunction without dilation, 5(8%) experienced RV dysfunction with RV dilation and no patient experienced acute cor pulmonale during ICU stay. Among the 18 patients with isolated RV dilation on ICU admission, 1(6%) experienced RV dysfunction with RV dilation and no patient experienced RV dysfunction without dilation or acute cor pulmonale during ICU stay. Among the 28 patients with RV dysfunction without dilation on ICU admission, 1(4%) experienced isolated RV dilation, 2(7%) experienced RV dysfunction with RV dilation and no patient experienced acute cor pulmonale during ICU stay. Among the 5 patients with RV dysfunction with RV dilation on ICU admission, 2(40%) experienced isolated RV dilation, 1(20%) experienced RV dysfunction without RV dilation and no patient experienced acute cor pulmonale during ICU stay. Among the 2 patients with acute cor pulmonale on ICU admission, 1(50%) experienced isolated RV dilation, 2(100%) experienced RV dysfunction with RV dilation and no patient experienced RV dysfunction without RV dilation during ICU stay. Figure S3: Cumulative incidence of the different right ventricular (RV) injury patterns during intensive care unit stay. Figure S4: Panel A: Cumulative incidence of Day-28 mortality according to the most severe right ventricular (RV) injury pattern during intensive care unit (ICU) stay (p-value according to log rank test). Panel B: Risk factors for Day-28 mortality. aHR: adjusted hazard ratio, CI: confidence interval, PaCO2: partial arterial pressure of carbon dioxide, RV: right ventricular. *Cardiovascular chronic disease = coronary artery disease + stroke + chronic heart failure. Table S1. Patient outcomes according to the presence of RV injury during ICU stay. Table S2. Patient characteristics, management and outcomes according to the RV injury pattern on ICU admission. Table S3. Echocardiographic variables during ICU stay in the whole population. Table S4. Ventilatory settings, oxygenation and hemodynamic variables when pooling all TTE examinations during ICU stay according to the RV injury pattern. Table S5. Number of patients with de novo RV injury during ICU stay. Table S6. Ventilatory settings, oxygenation and hemodynamic variables at TTE examination before and at the time of RV injury diagnosis in patients without RV injury on ICU admission. Table S7. Risk factors for Day-28 mortality. Table S8. Mixed effect logistic regression to assess the impact of RV injury on the Day-28 mortality rate.