Additional file 1: Figure S1. The required estimated number needed to harm for regular paracetamol users event of one case of liver cancer emerging. Compared to the control group, exposure to paracetamol resulted in 1 additional case of liver cancer per 10,000 users in the first year, and over time, 1 additional case of liver cancer per 1106 users at the10th year. Figure S2. E-value demonstrating required strength of unmeasured confounder to explain observed association between paracetamol use and liver cancer risk.
Funding
Scientific Research Project of Department of Education of Gansu Province The Natural Science Foundation of Gansu Province National Natural Science Foundation of China Medical Innovation and Development Project of Lanzhou University