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Additional file 1 of RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9

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posted on 2024-01-13, 04:40 authored by Mengli Zhang, Judith Hyle, Xiaowen Chen, Ye Xin, Yingcai Jin, Jianxiang Zhang, Xue Yang, Xinfeng Chen, Shaela Wright, Zhenling Liu, Wojciech Rosikiewicz, Beisi Xu, Liusheng He, Hong Liu, Nana Ping, Depei Wu, Feiqiu Wen, Chunliang Li, Peng Xu
Additional file 1. Figure 1S. Genome-wide CRISPR/Cas9 screening identifies RNA splicing factor RBM5 as a novel regulator for HOXA9 expression in acute leukemia. Figure 2S. Disruption of RBM5 delays the growth of leukemia cells in vitro. Figure 3S. RBM5 knockdown impairs in vivo myeloid leukemia engraftment. Figure 4S. RBM5 suppression does not affect human normal hematopoiesis. Figure 5S. Protein structure prediction of RBM5. Figure 6S. Identification of RBM5 downstream target genes in AML. Figure 7S. HOXA9 is a functional target gene of RBM5 in AML.

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Key Technologies Research and Development Program National Natural Science Foundation of China American Lebanese Syrian Associated Charities Science and Technology Support Program of Jiangsu Province Suzhou Gusu Medical Youth Talent

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    Genome Biology

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    Keywords

    CRISPR screenGenome editingRBM5HOXA9Acute myeloid leukemia

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