Additional file 1 of Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies

Additional file 1. Profiling E3 ligase expression at single cell level in different tissues. The heatmap shows the single-cell expression levels of 574 E3 ligases across all cell types and tissues in human adults from the Human Cell Landscape (HCL) data. In the heatmap, each row represents a cell type, and each column represents an E3 ligase. The color legend was shown on the right, which was determined by averaging the expression values of all cells within a tissue-specific cell type. These E3 ligases and the different cell types were clustered by the hierarchical clustering algorithm, and the resulting dendrograms were shown on bottom and right, respectively.