Additional file 1 of Practicalities in running early-phase trials using the time-to-event continual reassessment method (TiTE-CRM) for interventions with long toxicity periods using two radiotherapy oncology trials as examples

van Werkhoven, Erik; Hinsley, Samantha; Frangou, Eleni; Holmes, Jane; de Haan, Rosemarie; Hawkins, Maria; Brown, Sarah; Love, Sharon B

doi:10.6084/m9.figshare.12545087.v1

12874_2020_1012_MOESM1_ESM.pdf (222.4 kB)

Additional file 1 of Practicalities in running early-phase trials using the time-to-event continual reassessment method (TiTE-CRM) for interventions with long toxicity periods using two radiotherapy oncology trials as examples

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posted on 2020-06-23, 03:47 authored by Erik van Werkhoven, Samantha Hinsley, Eleni Frangou, Jane Holmes, Rosemarie de Haan, Maria Hawkins, Sarah Brown, Sharon B Love

Additional file 1. Dose Calculation for a TITE-CRM Study

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Medical Research Council Cancer Research UK

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Phase I Clinical trial design TiTE-CRM Late toxicity Dose-finding Adaptive trial design

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Additional file 1 of Practicalities in running early-phase trials using the time-to-event continual reassessment method (TiTE-CRM) for interventions with long toxicity periods using two radiotherapy oncology trials as examples

Funding

Medical Research Council Cancer Research UK

History

Usage metrics

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Keywords

Licence

Exports