Additional file 1 of Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies

Additional file 1. Appendix A. Search strategy. Appendix B. 517 extracted meta-analyses with exclusions identified. Appendix C. Assessment of duplicate meta-analyses. Appendix D. Description of 87 meta-analyses with poor reproducibility. Appendix E. Heterogeneity and small-study effects in included meta-analyses. Appendix F: Results of subgroup analysis of adjusted versus unadjusted effect estimates. Appendix G. Meta-regression results of NLR cut-off values. Appendix H. Excess significance in included meta-analyses. Appendix I: Grading of evidence (GRADE criteria). Appendix J: Effect size upgrading of GRADE. Appendix K. Sensitivity analysis of GRADE. Appendix L. Ranking based on precision versus effect size. Appendix M. AMSTAR 2 Quality Rating of Meta-analyses with Highly Suggestive or Strong Evidence. Appendix N. Assessment of quality of component studies. Appendix O: Sensitivity analysis of overall survival in rectal cancer.