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Additional file 1 of MARS: leveraging allelic heterogeneity to increase power of association testing

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posted on 2021-05-01, 03:25 authored by Farhad Hormozdiari, Junghyun Jung, Eleazar Eskin, Jong Wha J. Joo
Additional file 1 Fig. S2— MARS detects more eGenes in GTEx Whole Blood data. Fig. S3— Venn diagrams comparing eGenes identified by MARS using GTEx v6, eGenes reported by GTEx v6, and eGenes reported by GTEx v7 for all the tissues. Fig. S4— Compare p-values estimated from the standard sampling and those estimated from the importance sampling. Fig. S5— Venn diagrams comparing set-based association identified by MARS and the univariate test for traits in NFBC data. Fig. S6— Number of loci found by previous studies among the loci identified by MARS but not by the univariate test. Fig. S7—Power of MARS on the choice of priors on gamma. Fig. S8— Using only top 50 SNPs with bigger summary statistics well approximates the result using all the SNPs in MARS.

Funding

National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIT) MSIT(Ministry of Science and ICT), Korea, under the ITRC(Information Technology Research Center) support program Ministry of Trade, Industry and Energy (MOTIE) and Korea Institute for Advancement of Technology (KIAT) through the National Innovation Cluster R&D program

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