13046_2024_2996_MOESM1_ESM.docx (26.76 kB)

Additional file 1 of KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma

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posted on 2024-03-06, 04:40 authored by Hongshi Cai, Jianfeng Liang, Yaoqi Jiang, Ziyi Wang, Hongyu Li, Wenjin Wang, Cheng Wang, Jinsong Hou

Supplementary Material 1.

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National Natural Science Foundation of China Young Teacher Foundation of Sun Yat-sen University

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vivo experiments confirmed potential therapeutic strategy neck squamous carcinoma luciferase reporter assays cancer genome atlas colony formation assay associated transcriptional program associated genes obtained identified hnscc cell upstream transcription factors promoting cell proliferation klf7 regulates super exhibited aberrant expression study identified igf2bp2 driven igf2bp2 overexpression igf2bp2 overexpression mediated transwell migration assay gene expression omnibus identify hub genes promoting hnscc progression associated genes associated gene klf7 exhibited study reveals study aimed igf2bp2 transcription igf2bp2 promotes cas9 gene hub se increased expression high expression invasion assay managing hnscc hnscc tissues hnscc cells unfavorable prognosis positive correlation poor prognosis performed cck molecule inhibitors molecular mechanisms metastatic abilities many types malignant progression high aggressiveness greatly contributes editing system directly bind

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