Additional file 1 of Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification

Wang, Xinan; Zhang, Ziwei; Ding, Yi; Chen, Tony; Mucci, Lorelei; Albanes, Demetrios; Landi, Maria Teresa; Caporaso, Neil E.; Lam, Stephen; Tardon, Adonina; Chen, Chu; Bojesen, Stig E.; Johansson, Mattias; Risch, Angela; Bickeböller, Heike; Wichmann, H-Erich; Rennert, Gadi; Arnold, Susanne; Brennan, Paul; McKay, James D.; Field, John K.; Shete, Sanjay S.; Le Marchand, Loic; Liu, Geoffrey; Andrew, Angeline S.; Kiemeney, Lambertus A.; Zienolddiny-Narui, Shan; Behndig, Annelie; Johansson, Mikael; Cox, Angie; Lazarus, Philip; Schabath, Matthew B.; Aldrich, Melinda C.; Hung, Rayjean J.; Amos, Christopher I.; Lin, Xihong; Christiani, David C.

doi:10.6084/m9.figshare.25150611.v1

13073_2024_1298_MOESM1_ESM.docx (33.89 kB)

Additional file 1 of Impact of individual level uncertainty of lung cancer polygenic risk score (PRS) on risk stratification

journal contribution

posted on 2024-02-06, 05:21 authored by Xinan Wang, Ziwei Zhang, Yi Ding, Tony Chen, Lorelei Mucci, Demetrios Albanes, Maria Teresa Landi, Neil E. Caporaso, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Mattias Johansson, Angela Risch, Heike Bickeböller, H-Erich Wichmann, Gadi Rennert, Susanne Arnold, Paul Brennan, James D. McKay, John K. Field, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Angeline S. Andrew, Lambertus A. Kiemeney, Shan Zienolddiny-Narui, Annelie Behndig, Mikael Johansson, Angie Cox, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Rayjean J. Hung, Christopher I. Amos, Xihong Lin, David C. Christiani

Additional file 1: Table S1 Participating samples and their origin sites in the ILCCO lung cancer OncoArray project. Table S2 Information of 16 GWAS-derived lung cancer SNPs included in PRS-16 and PRS-16-CV. Table S3 Information of 19 GWAS-derived lung cancer SNPs that have been validated in Caucasians from prior studies. Table S4 Fine-mapped lung cancer risk variants that have been experimentally validated. Table S5 Rankings of individuals identified by three PRS models. Table S6 AUC of predicting lung cancer in the confident individuals.