Additional file 1 of Identifying the potential causal role of insomnia symptoms on 11,409 health-related outcomes: a phenome-wide Mendelian randomisation analysis in UK Biobank

Additional file 1: Text S1. UK Biobank Sample. Text S2. Insomnia Phenotype. Text S3. Sensitivity Analyses Methods. Text S4. Sensitivity Analysis Results. Figure S1. Flow chart of participant inclusion. Figure S2. Odds ratio and 95% confidence interval for association between each SNP used in the main GRS and insomnia in UK Biobank (Field 1200, with an answer of “usually” coded as an insomnia case). Figure S3. Odds ratio and 95% confidence interval for association between each SNP used in the S1 and S2 GRS and insomnia in UK Biobank (Field 1200, with an answer of “usually” coded as an insomnia case). Figure S4. Venn diagram of the number of GRS-outcome associations which passed the Bonferroni-corrected significance threshold for each MR-PheWAS (the percentages are with respect to the total number of associations (542) identified across all MR-pheWAS). Figure S5. Flow chart of GWAS inclusion for follow-up. Figure S6. Prisma style flow chart for article screening in systematic search.