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Additional file 1 of Hypoxia enhances human myoblast differentiation: involvement of HIF1α and impact of DUX4, the FSHD causal gene

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posted on 2023-12-17, 04:20 authored by Thuy-Hang Nguyen, Lise Paprzycki, Alexandre Legrand, Anne-Emilie Declèves, Philipp Heher, Maelle Limpens, Alexandra Belayew, Christopher R. S. Banerji, Peter S. Zammit, Alexandra Tassin
Additional file 1: Figure S1. Hypoxia enhances early and late differentiation of control 54-6 human myoblasts.

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Fonds De La Recherche Scientifique - FNRS Association Belge contre les Maladies Neuro-Musculaires Amis FSH UMONS-UNAMUR Medical Research Council Austrian Science Fund FSHD Society Friends of FSH Research

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    Skeletal Muscle

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    myosin heavy chaindependent early stepsevaluated proliferation ratedux4 could interferemuscle cell proliferationhif1α interplay indicatesfshd pathological contexthypoxic response pathwayhypoxia also enhancedfshd muscle performancemuscle regeneration defectsdux4 suppressed hif1αimpact myoblast proliferationhuman immortalized myoblastshypoxic responsemuscle regenerationhif1α functionfshd ).used myogeninpositive nucleipositive areaparticular interestnovel mechanismmyogenic programmechanisms underlyinginducible expressionindependent manneridux4 myoblastshuman myocyteshealthy myoblastsfusion indexfunction experimentsfacioscapulohumeral dystrophyedu incorporation4 days21 %)1 %).

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