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Additional file 1 of Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson’s disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity

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posted on 2020-07-11, 04:06 authored by Rodney C. P. Go, Michael J. Corley, G. Webster Ross, Helen Petrovitch, Kamal H. Masaki, Alika K. Maunakea, Qimei He, Maarit I. Tiirikainen
Additional file 1: Table S1. Distribution of DML in brain and blood between PD cases with 0 years of plantation work (n = 13) and PD cases with 10+ years of plantation work (n = 4). Table S2. DML with p < 0.001 and the number of associated annotated genes. Table S3. Distribution of DML in brain and blood between PD cases with 4+ OGCs (n = 4) and PD cases with 0–2 OGCs (n = 12) detected in brain tissue. Table S4. HumanMethylation450K BeadChip Analysis and Pyrosequencing correlation.

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Michael J. Fox Foundation for Parkinson's Research U.S. Army Medical Research Acquisition Activity National Institute of Neurological Disorders and Stroke National Institute on Aging Office of Research and Development National Institutes of Health

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    BMC Neuroscience

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    Keywords

    Parkinson’s diseaseOrganochlorinesPlantation workGenome-wide DNA methylationGliaNeuroinflammationMitochondrial dysfunctionNeurodegeneration

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