Additional file 1 of Effects of extracorporeal CO2 removal on gas exchange and ventilator settings: a systematic review and meta-analysis

Additional file 1. Additional File A. PRISMA 2020 checklist. Additional File B. Criteria for considering studies for this review. Additional File C. Search strategy. Additional Table S1. Studies. Additional Table S2. Devices designed for ECCO2R and their basic specifications. Additional Table S3. Available data from included studies. Additional Table S4. Adverse Events from observational studies. Additional Figure S1: Risk of bias assessment (Robins-I tool). Additional Figure S2 a, and b: Change of (a) PaCO2, mmHg and (b) pH within 24 hours after initiating ECCO2R (all studies). Additional Figure S3 a, and b: Change of (a) PaO2/FiO2 ratio, mmHg and (b) PEEP, cmH2O within 24 hours after initiating ECCO2R (all studies). Additional Figure S4 a, b, and c: Change of (a) plateau pressure, cmH2O, (b) tidal volume, mL, and (c) respiratory rate, breaths/min within 24 hours after initiating ECCO2R (all studies). Additional Figure S5 a, and b: Change of (a) PaO2/FiO2 ratio, mmHg and (b) PEEP, cmH2Owithin 24 hours after initiating ECCO2R (diagnoses subgroups). Additional Figure S6 a, and b: Change of (a) PaCO2, mmHg (a) and (b) PaO2/FiO2 ratio, mmHg within 24 hours after initiating ECCO2R according to diagnosis and extraction. Additional Figure S7 a, and b: Change of (a) PaO2/FiO2 ratio, mmHg and (b) PEEP, cmH2O within 24 hours after initiating ECCO2R (lower extraction and higher extraction subgroups). Additional Figure S8 a, and b: Change of (a) PaO2/FiO2 ratio, mmHg and (b) PEEP, cmH2O within 24 hours after initiating ECCO2R according to diagnosis and extraction. Additional Figure S9 a, and b: Change of (a) plateau pressure, cmH2O and (b) tidal volume, mL within 24 hours after initiating ECCO2R (lower extraction and higher extraction subgroups). Additional Figure S10 a, b, and c: Change of (a) plateau pressure, cmH2O, (b) tidal volume, mL, and (c) respiratory rate, breaths/min within 24 hours after initiating ECCO2R according to diagnosis and extraction. Additional Figure S11 a-g: (a) PaCO2, mmHg, (b) pH, (c) PaO2/FiO2 ratio, mmHg and (d) PEEP, cmH2O, (e) plateau pressure, cmH2O, (f) tidal volume, mL and (g) respiratory rate, breaths/min according to risk of bias.