40478_2023_1699_MOESM1_ESM.docx (17.31 kB)
Additional file 1 of Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy
journal contribution
posted on 2024-01-03, 05:02 authored by Y. Schneider, C. Gauer, M. Andert, A. Hoffmann, M. J. Riemenschneider, W. Krebs, N. Chalmers, C. Lötzsch, U. J. Naumann, W. Xiang, V. Rothhammer, R. Beckervordersandforth, J. C. M. Schlachetzki, J. WinklerAdditional file 1: List of primers used for qPCR.
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Medical Research Foundation Deutsche Forschungsgemeinschaft Bayerisches Staatsministerium für Bildung und Kultus, Wissenschaft und Kunst Universitätsklinikum Erlangen (8546)
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similar astrocytic phenotypeneuropathology remains elusivemultiple system atrophyglutamate transporter 1glutamate aspartate transporterdysregulated genes involvedmyelinogenic expression patterngene expression profileinflammatory transcripts accompanieddichotomous astrocytic profiletransgenic msa micemsa mice exhibitedrelated neurodegenerative processesincreased astrocyte reactivitymotor cortex displayedneurodegenerative processesdecreased expressionmotor cortexinflammatory signatureincreased oligodendroglialdichotomous roleastrocyte subtypesmsa suggestingmsa patientsmsa ),transcriptomic landscapesubstantia nigrastriatum —specific contributionneurological disordershomeostatic functionsgrowing recognitionfirst setdifferential rolecalcium metabolismbasal ganglia
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