13059_2021_2494_MOESM1_ESM.pdf (1.36 MB)
Additional file 1 of Differential regulation of mRNA fate by the human Ccr4-Not complex is driven by coding sequence composition and mRNA localization
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posted on 2021-10-07, 03:38 authored by Sarah L. Gillen, Chiara Giacomelli, Kelly Hodge, Sara Zanivan, Martin Bushell, Ania WilczynskaAdditional file 1. Supplementary figures.
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Cancer Research UK Medical Research Council Medical Research Council Biotechnology and Biological Sciences Research Council
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reduced translational efficiencypromoting amino acidsmajor factor coordinatinginterlinked biochemical processesamino acid usageprotein production transcriptomeglobal integrated viewcoding sequence compositionstate mrna levelsmrna life cyclekey mrna featurestranslationally upregulated mrnastranscriptional regulation mediatedprotein synthesis ratecomplex assessing steadyprotein synthesisprotein outputglobal upregulationcodon compositionmrna localizationmrna fateindividual mrnamrnas targetedmrnas enrichedspecifically downstreamribosome positionrapid adaptationpreferential stabilizationprecise controlnormally localizedmechanism linkedinvestigate postgene expressionending codonsdynamic changesdifferential regulationdespite playingcontain disordercomprehensive approachcell ’also uncover
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