Additional file 1 of Cost-effectiveness analysis of first-line treatment with crizotinib in ROS1-rearranged advanced non-small cell lung cancer (NSCLC) in Canada

Additional file 1: Additional information regarding the clinical data and model results. Table 1. Studies of crizotinib and chemotherapy for ROS1+ advanced NSCLC. Table 2. Summary of studies used to calculate risk of progression with second- and third-line docetaxel and checkpoint inhibitors. Table 3. List of scenario analyses. Fig. 1. PRISMA flow chart for ROS1 studies. Fig. 2. Kaplan-Meier curve from combined analysis for progression-free survival (PFS) among ROS1+ NSCLC patients. Fig. 3. Kaplan-Meier curve of PROFILE 1014 for progression-free survival (PFS) among ALK+ NSCLC patients for each treatment. Fig. 4. Kaplan-Meier curve and parametric curve of combined analysis for progression-free survival (PFS) for each treatment group with hazard ratio applied to patients undergoing maintenance pemetrexed in chemotherapy group. Fig. 5. Results from one-way deterministic sensitivity analysis.