Additional file 1 of Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study
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posted on 2025-03-13, 04:43 authored by Lantian Xu, Chihua Li, Allison E. Aiello, Kenneth M. Langa, Jennifer B. Dowd, Rebecca C. Stebbins, Helen C. S. Meier, Ziman Jiang, Grace A. Noppert, Gen LiSupplementary Material 1
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united states providestop selected logratiossupervised learning analysesinnovative analytical approacheshierarchical tree structuredimension reduction techniquesconducted two setschronic disease indexstepwise redundancy analysisnetwork analysis showedstudy included 6pairwise logratio measuresmap relationships amonglinear penalized loghigher frailty levelslevel immune datacentral memory cd8central memory cd4capture main variancethree health outcomesbetter health outcomescontrast models showedb subset cellsidentified subset cellshealth outcomescompositional analysisterm relationshipssubset cellsretirement studyratio measureslinear regressionscontrast modelshigher ratiohigher proportionsimmune systemimmune compositionreported healthunique opportunityrelated diseasesratios reinforcednaïve cd4median agelower proportiongradual deteriorationdetailed populationbased approach250 participants
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