13148_2022_1351_MOESM1_ESM.pdf (343.66 kB)
Additional file 1 of Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans
journal contribution
posted on 2022-10-17, 03:14 authored by Hannah R. Elliott, Kimberley Burrows, Josine L. Min, Therese Tillin, Dan Mason, John Wright, Gillian Santorelli, George Davey Smith, Deborah A. Lawlor, Alun D. Hughes, Nishi Chaturvedi, Caroline L. ReltonAdditional file 1. Figure S1. Principal component analysis of SABRE genetic data. The upper panels show PCs 1 and 2 generated from SABRE or BiB data. The lower panels show PCs 1 and 2 generated from SABRE + HapMap3 data or BiB + HapMap3 data. Colours indicate self-reported ethnic group or subgroup (SABRE, BiB) or population group (HapMap3). Axis labels show the variance explained by each PC. HapMap3 populations have been collapsed: South Asian = GIH; European = CEU + TSI; African = ASW + LWK + MKK; Mexican = MEX; South East Asian = CHB + CHD + JPT. In the lower panel (SABRE), two outliers self-reporting as South Asian in SABRE data appear intermediate between African groups from HapMap3 and the remaining South Asian cluster. Both of these individuals reported their country of birth as an African country indicating possible genetic admixture in these individuals. These two individuals were removed from all other analyses. In the lower panel (SABRE), “other South Asian” individuals predominantly identify their country of birth as South Asia (India, Pakistan, Bangladesh, Sri Lanka), n = 42/50.
