Additional file 1: of CDP7657, an anti-CD40L antibody lacking an Fc domain, inhibits CD40L-dependent immune responses without thrombotic complications: an in vivo study
journal contribution
posted on 2015-09-03, 05:00 authored by Anthony Shock, Linda Burkly, Ian Wakefield, Christopher Peters, Ellen Garber, Janine Ferrant, Frederick Taylor, Lihe Su, Yen-Ming Hsu, David Hutto, Ali Amirkhosravi, Todd Meyer, John Francis, Sarah Malcolm, Martyn Robinson, Derek Brown, Stevan Shaw, Roland Foulkes, Alastair Lawson, Olivier Harari, Timothy Bourne, Alison Maloney, Neil WeirInhibition of secondary immune response in Cynomolgus monkeys. CDP7657 at 5 or 20 mg/kg (60 mg/kg was not evaluated in this study) was compared with hu5c8 at 20 mg/kg. Animals were administered a single dose of antibody or i.v saline. and challenged with tetanus toxoid (TT) on day 1; they then received a second dose of antibody and TT on day 30. Data are expressed as the mean anti-TT IgG titerâÂąâstandard deviation; approximately 50 % inhibition was observed at 20 mg/kg CDP7657, although this was not statistically significant. ***P <0.001 (one-way analysis of variance) compared with control; NS not significant. (PDF 66 kb)
