Additional file 1 of CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice

Bhargavan, Biju; Woollard, Shawna M.; McMillan, Jo Ellyn; Kanmogne, Georgette D.

doi:10.6084/m9.figshare.17065815.v1

13024_2021_500_MOESM1_ESM.pdf (4.94 MB)

Additional file 1 of CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice

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posted on 2021-11-23, 04:32 authored by Biju Bhargavan, Shawna M. Woollard, Jo Ellyn McMillan, Georgette D. Kanmogne

Additional file 1: Supplemental Fig. 1. Lower magnification (4x) images show the mice brain regions analyzed. a: somatosensory cortex (CTX); b: hippocampus fimbria (Fba); MG: meningeal areas

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National Institute of Mental Health

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HIV-1 NSG mice Amyloid-beta Tau phosphorylation Neuronal damage Blood-brain barrier injury CCR5 Maraviroc Monocytes-derived macrophages Human brain microvascular endothelial cells RAGE LRP1

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Additional file 1 of CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice

Funding

National Institute of Mental Health

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