Additional file 1 of Bedside personalized methods based on electrical impedance tomography or respiratory mechanics to set PEEP in ARDS and recruitment-to-inflation ratio: a physiologic study

Additional file 1: Table S1. Presentation and computation of physiological parameters used in the study. Figure S1. Study protocol, represented by PEEP level across time. Figure S2. Correlation between estimated recruitment-to-inflation (R/I) ratio, based on change in end-expiratory lung volume measured by electrical impedance tomography (EIT) and R/I ratio based on the single breath trial (SBT) method. Figure S3. Optimal Positive End Expiratory Pressure (PEEP) computed according to the COVID-19 status. Figure S4. Correlations between recruitability assessed by recruited volume standardized for predicted body weight (VREC/PBW) and optimal PEEP levels. Figure S5. Correlations between recruitability assessed by the difference in lung collapse between PEEP 20 and 5 cmH2O (· Collapse20-5) and optimal PEEP levels. Figure S6. Optimal Positive End-Expiratory Pressure (PEEP) level computed after the decremental PEEP trial among patients with Lower (blue boxes, n=10) and Higher (red boxes, n=9) Recruitment-to-Inflation ratio estimated by Electrical Impedance Tomography (R/Iest). Figure S7. Optimal Positive End-Expiratory Pressure (PEEP) level computed after the decremental PEEP trial. Figure S8. Correlations between respiratory system compliance (CRS, panel A) or ratio between arterial pressure in dioxygen and inspired fraction in dioxygen (PaO2/FiO2, panel B) and recruitment-to-inflation ratio estimated by Electrical Impedance Tomography (R/Iest). Figure S9. Graphic representation of the mathematical variations in lung overdistension (OD) and collapsus (LC) induced by the changes in acquisition window.