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Additional file 1 of A universal in silico V(D)J recombination strategy for developing humanized monoclonal antibodies

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posted on 2022-02-01, 04:54 authored by Yuan-Chin Hsieh, Jun-min Liao, Kuo-Hsiang Chuang, Kai-Wen Ho, Shih-Ting Hong, Hui-Ju Liu, Bo-Cheng Huang, I-Ju Chen, Yen-Ling Liu, Jaw-Yuan Wang, Hsiang-Lin Tsai, Yu-Cheng Su, Yen-Tseng Wang, Tian-Lu Cheng
Additional file 1. Supplementary information: Table S1. Calculated wRMSDi values of the anti-EGFR a4.6.1 mAb and experimental results. Figure S1. Correlation of wRMSDi with the log(EC50) of the anti-EGFR a4.6.1 mAb. Table S2. Calculated wRMSDi values of the anti-GPC3 YP9.1 scFv and experimental results. Figure S2. Correlation of wRMSDi with the log(EC50) of the anti-GPC3 YP9.1 scFv. Table S3. Calculated wRMSDi values and experimental results of the humanized anti-α4β1 integrin variants. Figure S3. Correlation of wRMSDi with the log(EC50) of humanized anti-α4β1 integrin variants. Table S4. Correlation between RMSDi and log(EC50) or log(KD) with and without weighting adjustments.

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Ministry of Science and Technology, Taiwan National Health Research Institutes Academia Sinica Ministry of Education Kaohsiung Medical University

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