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Additional file 1 of A novel targeted NGS panel identifies numerous homologous recombination deficiency (HRD)-associated gene mutations in addition to known BRCA mutations
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posted on 2024-01-07, 04:20 authored by Anne Vogel, Anna Haupts, Michael Kloth, Wilfried Roth, Nils HartmannSupplementary Material 1
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Universitätsmedizin der Johannes Gutenberg-Universität Mainz (8974)
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synthetic lethality approachessignificant therapeutic relevancereliable panel performancepresent study provespresent retrospective studyfrequently altered genebrca mutation statusresistance mutations acquiredpreviously known mutationspatients may benefithrd panel resultslikely pathogenic mutations24 %) patients90 samples includednew pathogenicharbor mutationstreatment timetaken togethersubstantial numberrobustly detectedprostate cancerpivotal roleparp inhibitorshomologous recombinationffpe tissueeasily screenbrca2 playbrca2 genesassociated genes73 %).22 %)
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