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Additional file 19 of SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

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posted on 2021-08-11, 03:34 authored by Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, Marta Milo, Guillaume M. Hautbergue
Additional file 19 : Supplementary Figure 5. Orthologous gene changes in the human and fly C9-disease groups. 48 orthologues show conserved direction of differential expression at gene level (DEGs) while 33 others exhibit opposite direction of changes. Green and red labels respectively correspond to up-regulation and down-regulation of the expression levels of the corresponding transcripts.

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Motor Neurone Disease Association Biotechnology and Biological Sciences Research Council Medical Research Council Royal Society International Research and Exchanges grant Fondation Thierry Latran Academy of Medical Sciences Springboard Award H2020 European Research Council Alzheimer's Research UK NIHR Sheffield Biomedical Research Centre

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    Molecular Neurodegeneration

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    Amyotrophic lateral sclerosisC9ORF72-repeat expansionsPre-clinical modelsTranscriptomeGenome-wide mechanisms of neuroprotectionSRSF1-dependent RNA nuclear exportDisease-modifying gene expression signatureVoltage-gated potassium ion channel

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