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Additional file 12 of Elucidating the role of the gut microbiota in the physiological effects of dietary fiber

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journal contribution
posted on 14.05.2022, 05:10 by Edward C. Deehan, Zhengxiao Zhang, Alessandra Riva, Anissa M. Armet, Maria Elisa Perez-Muñoz, Nguyen K. Nguyen, Jacqueline A. Krysa, Benjamin Seethaler, Yuan-Yuan Zhao, Janis Cole, Fuyong Li, Bela Hausmann, Andreas Spittler, Julie-Anne Nazare, Nathalie M. Delzenne, Jonathan M. Curtis, Wendy V. Wismer, Spencer D. Proctor, Jeffrey A. Bakal, Stephan C. Bischoff, Dan Knights, Catherine J. Field, David Berry, Carla M. Prado, Jens Walter
Additional file 12: Figure S5. Associations between the effects on perceived satiety and surrogate endpoints and the dominant fecal microbiota features affected by fiber supplementation. Heatmap shows cubed-root transformed β-coefficients of univariate generalized linear models performed on the compositional (dominant AX-responsive taxa at baseline, shifts, and ex vivo) and functional (fecal propionate and bile acid shifts) features of the gut microbiota. Statistical significance was considered at FDR corrected q values < 0.05. ∆, absolute change from baseline to week 6; %∆, percent change from baseline to week 6; 7αOHCA; 7αOH-3-oxo-4-cholestenoic acid; ApoCA; apocholic acid; ASV, amplicon sequence variant; AUC, area under the curve; AX, arabinoxylan; BL, baseline; HDCA, hyodeoxycholic acid; HOMA-IR, homeostatic model assessment of insulin resistance; MCC, microcrystalline cellulose; OTU, operational taxonomic unit; TNF-α, tumor necrosis factor-α.

Funding

European Research Council Joint Programming Initiative A healthy diet for a healthy life Science Foundation Ireland Centre

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